This is an objective based learning portal for Neurology Aspirants. It provides multiple choice questions for the preparation of various neurology entrance examinations. The Neurology: Self-Assessment And Review book is a comprehensive neurology question bank.
Which of the following is a Histone Deacetylase Inhibitor?
Question: Which of the following is a Histone Deacetylase Inhibitor?
Histone Deacetylase Inhibitor
Histone deacetylase-9 (HDAC9) gene is associated with pathogenesis of large artery ischemic stroke. HDAC9 inhibitor may prevent ischemic stroke. Sodium Valproate is a nonspecific Histone Deacetylase Inhibitor. Sodium Valproate therapy given after ischemic stroke may be associated with reduced recurrent stroke rate.
Brookes RL, Crichton S, Wolfe CD, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke. 2018 Jan;49(1):54-61.
Multiple Choice Questions in Neurology:
A 60 year old male patient, known case of Diabetes mellitus and chronic hypertension, presented with sudden onset of right sided hemiparesis and altered mental status. The patient was aspirated and gasping in the emergency room. He was immediately intubated and put on ventilatory support in an intensive care ward. While the patient was on ventilator, doctor examined the patient. He was able to localize painful stimulus from left side of hand. He was able to open eyes on painful stimulus, but unable to open eyes on voice command. What was the Glasgow Coma Scale (GCS) of that patient? 681012Recommendations:
Glasgow Coma Scale is very frequently asked topic in neurology entrance examination question paper. This topic should be included in your neurology question bank. Glasgow Coma Scale (GCS) in Tracheostomized or Intubated Patients
Glasgow Coma Scale is a neurological scale to assess the level of consciousness of the patient. It is developed by Gr…
How many spinal arteries supply the human spinal cord?Three ArteriesFour ArteriesFive ArteriesTwo ArteriesBlood Supply of Spinal CordArterial Supply
The spinal cord is supplied by Three Longitudinal Arteries: One Anterior Spinal Artery supplies the anterior two-thirds of the spinal cord.Two Posterior Spinal Arteries supply the posterior one-third of the spinal cord.[Mnemonics: Posterior is Paired, Posterior = Paired] Venous Drainage
There is a complex network of intrinsic, extrinsic, and extradural systems. The anterior and posterior spinal veins and anterior and posterior radicular veins are freely communicate with the internal vertebral plexus in the epidural space. This drains into the cerebral dural venous sinuses and cerebral veins as well as the external vertebral plexus. The veins of the spinal cord and vertebral column are valveless. Reference:
Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen‐Gadol AA. Blood supply to the human spinal cord: part I. Anatomy and hemodynamics. Clinical…
High Yield Facts ⭆ Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. Motor neurons release acetylcholine (ACh) neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine ionotropic receptors (nAChRs) on the cell membrane of the muscle fiber. The binding of ACh to the receptor can depolarize the muscle fiber, results in muscle contraction. Normally, Acetylcholine (ACh) binds to α-subunit of Acetylcholine Receptor (AChR) at postsynaptic junction. Which ion is responsible for transmission of impulse from postsynaptic junction to nerve fibers?Chloride (Cl)Calcium (Ca)Sodium (Na)Magnesium (Mg)Neuromuscula…