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Which of the following is a Histone Deacetylase Inhibitor?
Question: Which of the following is a Histone Deacetylase Inhibitor?
Histone Deacetylase Inhibitor
Histone deacetylase-9 (HDAC9) gene is associated with pathogenesis of large artery ischemic stroke. HDAC9 inhibitor may prevent ischemic stroke. Sodium Valproate is a nonspecific Histone Deacetylase Inhibitor. Sodium Valproate therapy given after ischemic stroke may be associated with reduced recurrent stroke rate.
Brookes RL, Crichton S, Wolfe CD, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke. 2018 Jan;49(1):54-61.
How many spinal arteries supply the human spinal cord?Three ArteriesFour ArteriesFive ArteriesTwo ArteriesBlood Supply of Spinal CordArterial Supply
The spinal cord is supplied by Three Longitudinal Arteries: One Anterior Spinal Artery supplies the anterior two-thirds of the spinal cord.Two Posterior Spinal Arteries supply the posterior one-third of the spinal cord.[Mnemonics: Posterior is Paired, Posterior = Paired] Venous Drainage
There is a complex network of intrinsic, extrinsic, and extradural systems. The anterior and posterior spinal veins and anterior and posterior radicular veins are freely communicate with the internal vertebral plexus in the epidural space. This drains into the cerebral dural venous sinuses and cerebral veins as well as the external vertebral plexus. The veins of the spinal cord and vertebral column are valveless. Reference:
Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen‐Gadol AA. Blood supply to the human spinal cord: part I. Anatomy and hemodynamics. Clinical…
#The Neurology Question: True & False: Restless Legs Syndrome Symptoms start with sleep Dystonia and myoclonus Symptoms aggravate with dopaminergic agonist Normal Brain MRI Sensory symptoms on awakening(Source: The Neurology: Self-Assessment & Review By Dr. Sunil Kumar, www.theneurology.org)
Reference: Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Med. 2008;9(7):770-781.
Restless legs syndrome affects approximately 10% of the adult population. Clinical FeaturesThe four core symptoms required for diagnosis are as follows: An urge to move the legs: usually caused or accompanied by an unpleasant sensation in the legs Symptoms begin or worsen with rest Partial or complete relief by movement Worsening during the evening or nightSymptoms most commonly begin in the legs, but can spread to or even begin in the upper limbs. The unpleasant sensation is often described as a creepy-crawly feeling, par…