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Which of the following is a Histone Deacetylase Inhibitor?

Question: Which of the following is a Histone Deacetylase Inhibitor?

  1. Phenytoin
  2. Sodium Valproate
  3. Carbamazepine
  4. Levetiracetam 

Histone Deacetylase Inhibitor

Histone deacetylase-9 (HDAC9) gene is associated with pathogenesis of large artery ischemic stroke. HDAC9 inhibitor may prevent ischemic stroke. Sodium Valproate is a nonspecific Histone Deacetylase Inhibitor. Sodium Valproate therapy given after ischemic stroke may be associated with reduced recurrent stroke rate.

Reference:

Brookes RL, Crichton S, Wolfe CD, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke. 2018 Jan;49(1):54-61.

[Answer is 2. Sodium Valproate]

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