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Which of the following is a Histone Deacetylase Inhibitor?

Question: Which of the following is a Histone Deacetylase Inhibitor?PhenytoinSodium ValproateCarbamazepineLevetiracetam  Histone Deacetylase Inhibitor Histone deacetylase-9 (HDAC9) gene is associated with pathogenesis of large artery ischemic stroke. HDAC9 inhibitor may prevent ischemic stroke. Sodium Valproate is a nonspecific Histone Deacetylase Inhibitor. Sodium Valproate therapy given after ischemic stroke may be associated with reduced recurrent stroke rate. Reference: Brookes RL, Crichton S, Wolfe CD, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke. 2018 Jan;49(1):54-61. [Answer is 2. Sodium Valproate]


#Neurology Aspirants!
The new edition of “The Neurology: Self-Assessment & Review” is published by Aditya Publication. This book is a comprehensive collection of DM Neurology Entrance Examination question papers from various reputed Indian Neurology Institutes, which are frequently asked in neurology entrance examinations. This book will be an effective guide for self-assessment and rapid revision.
-Updated question papers with new chapters
-Chapter-wise arrangement of questions
-User-friendly layout of the chapters
-Comprehensive neurology coverage
-3350 Pre-DM Neurology Entrance Examination Questions with Answers and Explanation
-Also included Pre-DM Medicine Entrance Examination Questions
-Include question papers from major Pre-DM Neurology Entrance Examination in India (AIIMS, SGPGI, Chandigarh PGI, NIMHANS, RUHS and Delhi University)
-Contains original & authenticated memory based…

Restless Legs Syndrome

#The Neurology
Question: True & False: Restless Legs Syndrome
Symptoms start with sleep Dystonia and myoclonus Symptoms aggravate with dopaminergic agonist Normal Brain MRI Sensory symptoms on awakening(Source: The Neurology: Self-Assessment & Review By Dr. Sunil Kumar,

Reference: Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Med. 2008;9(7):770-781.

Restless legs syndrome affects approximately 10% of the adult population.
Clinical FeaturesThe four core symptoms required for diagnosis are as follows: An urge to move the legs: usually caused or accompanied by an unpleasant sensation in the legs Symptoms begin or worsen with rest Partial or complete relief by movement Worsening during the evening or nightSymptoms most commonly begin in the legs, but can spread to or even begin in the upper limbs. The unpleasant sensation is often described as a creepy-crawly feeling, par…

Muscle Biopsy