Showing posts from February, 2019

A Home For Neurology Aspirants!

Blood Supply of Spinal Cord

How many spinal arteries supply the human spinal cord?Three ArteriesFour ArteriesFive ArteriesTwo ArteriesBlood Supply of Spinal CordArterial Supply The spinal cord is supplied by Three Longitudinal Arteries: One Anterior Spinal Artery supplies the anterior two-thirds of the spinal cord.Two Posterior Spinal Arteries supply the posterior one-third of the spinal cord.[Mnemonics: Posterior is Paired, Posterior = Paired] Venous Drainage There is a complex network of intrinsic, extrinsic, and extradural systems. The anterior and posterior spinal veins and anterior and posterior radicular veins are freely communicate with the internal vertebral plexus in the epidural space. This drains into the cerebral dural venous sinuses and cerebral veins as well as the external vertebral plexus. The veins of the spinal cord and vertebral column are valveless.
Reference: Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen‐Gadol AA. Blood supply to the human spinal cord: part I. Anatomy and hemodynamics. Clinical…

Which of the following is a Histone Deacetylase Inhibitor?

Question: Which of the following is a Histone Deacetylase Inhibitor?PhenytoinSodium ValproateCarbamazepineLevetiracetam  Histone Deacetylase Inhibitor Histone deacetylase-9 (HDAC9) gene is associated with pathogenesis of large artery ischemic stroke. HDAC9 inhibitor may prevent ischemic stroke. Sodium Valproate is a nonspecific Histone Deacetylase Inhibitor. Sodium Valproate therapy given after ischemic stroke may be associated with reduced recurrent stroke rate. Reference: Brookes RL, Crichton S, Wolfe CD, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke. 2018 Jan;49(1):54-61. [Answer is 2. Sodium Valproate]